International Journal of Hematology and Oncology 2017, Vol 27, Num 3 Page(s): 185-192
The Role of Autophagia in Non-Small Cell Lung Cancer

Ozlem N. SEVER1, Gokhan DEMIR1

Maslak Acıbadem Hospital, Department of Medical Oncology, Istanbul, TURKEY

Keywords: Autophagy, Cell death, NSCLC, Prognosis
Lung cancer is the most common type of cancer all over the world and first rank in cancer related deaths. Autophagy was first defined in yeast at the 1970’s, programmed cell death mechanism. In recent years, many studies have been made regarding the role of the autophagy in carsinogenesis. In these studies, autophagy both initiate the carcinogenesis and providing survival of cancer cells as well as launching their apoptosis, as opposed to this two role as a mechanism to destroy cancer cells in the direction of that evidence to the task. Especially in the treatment manipulation of autophagy may have some future treatment opportunities (inhibition or activation). But we have not yet to clarify these questions so the data are inadequate. One of the greatest obstacles in treatment of lung cancer is dysregulation of cancer cell death signalization. In this study we evaluate the autophagy genes expression mechanisms in relation with the expressions of genes in different pathological types in different clinical stages of lung cancer. But due to some technical data on gene expression in yield of negativity did not reach significant information.